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Veterinary Research Forum، جلد ۱۶، شماره ۱۰، صفحات ۵۹۱-۵۹۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of allogenic biomaterial on the development of adjuvant arthritis in mature female rats
چکیده انگلیسی مقاله The administration of dispersed allogeneic biomaterial (AB) into the para-articular region and joint cavity allows slowing down the processes of tissue destruction in arthritis. The aim of the study was to examine the effect of AB on the course of experimental adjuvant arthritis (AA) in rats. For modeling of AA, complete Freund's adjuvant was injected into the plantar surface of the hind paw of 60 white outbred female rats. The study included intact group, control group, and experimental group. After 37 days of the experiment, blood was collected for hematological analysis and the knee joint with surrounding tissues was harvested for standard histological examination. Intra-articular administration of AB to experimental rats while using complete Freund's adjuvant neutralized the manifestation of signs of a generalized inflammatory process in the joints and reduced the degree of destructive changes in the articular apparatus, preserving the structure of the cartilaginous layer. The use of AB made it possible to stabilize the red and white blood cells levels in the experimental group, as well as significantly increase the reduced level of monocytes. Intra-articular administration of AB during AA modeling exhibits an osteo- and chondro-protective effect, providing positive anti-inflammatory and symptom-modifying effects and weakening the manifestation of pathomorphological changes in the joints of experimental rats.
کلیدواژه‌های انگلیسی مقاله adjuvant arthritis,allogeneic biomaterial,chondroprotection,osteoprotection,Rat
نویسندگان مقاله Musina Lyalya Akhiyarovna |
Russian Eye and Plastic Surgery Centre, Bashkir State Medical University, Ufa, Russia

Lebedeva Anna Ivanovna |
Russian Eye and Plastic Surgery Centre, Bashkir State Medical University, Ufa, Russia

Nazmutdinov Bulat Rinatovich |
Russian Eye and Plastic Surgery Centre, Bashkir State Medical University, Ufa, Russia

Prusakov Alexey Viktorovich |
Faculty of Veterinary Medicine, Saint Petersburg State University of Veterinary Medicine, Saint Petersburg, Russia

Yashin Anatoly Viktorovich |
Faculty of Veterinary Medicine, Saint Petersburg State University of Veterinary Medicine, Saint Petersburg, Russia

Ponamarev Vladimir Sergeevich |
Faculty of Veterinary Medicine, Saint Petersburg State University of Veterinary Medicine, Saint Petersburg, Russia

نشانی اینترنتی https://vrf.iranjournals.ir/article_729415_30a5fb542121ff1fd5afa0be25d3c955.pdf
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