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Iranian Journal of Microbiology، جلد ۱۷، شماره ۵، صفحات ۶۶۹-۶۸۱
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عنوان انگلیسی Diagnostic value comparative analysis of the commercial kits for the detection of SARS-CoV-2 in clinical samples: a systematic review and meta-analysis
چکیده انگلیسی مقاله Background and Objectives: Rapid and accurate identification of suspicious SARS-CoV-2 patients is essential in controlling the infection. Numerous commercial kits are developed which target diverse regions of the SARS-CoV-2 virus genome. This systematic review addresses the lack of comprehensive analyses comparing the diagnostic value of commercial kits for SARS-CoV-2 detection. We aimed to compare diagnostic value of commercial SARS-CoV-2 kits in clinical samples using a systematic review and meta-analysis method. Materials and Methods: A comprehensive search was conducted on main databases of Medline (PubMed), Embase, Web of Science and Scopus from 2019 to October 2021 using the appropriate keywords. Systematic Reviews and Meta-Analysis guideline PRISMA checklist was used to select eligible studies. Results: The most frequent introduced kits were from USA (33 cases) and China (27). Among all studies, 11, 9 and 7 papers had assessed FDA –CDC, Sansure and Allplex kits, respectively. The majority of the kits were based on RT-PCR (52 cases) and the most frequent genes target was N protein (63 cases). The overall sensitivity of the kits was 80.5%. The lowest sensitivity was reported for Daan Kit, while the highest sensitivity was seen for many kits. The specificity of the kits ranged from 87.9% to 99.8% and the overall specificity was 97.9%. Both PPV and NPV of the kits ranged from 87.9% to 99.8% for PPV and 82.9% to 99.8% for NPV. Conclusion: Based on DOR obtained from three different formulas, GeneFinder, InBios, NxTAG, Simplexa and FDA-CDC kit have better detection performance. The GeneFinder Kit appears to be among the more suitable options regarding cost-effectiveness for each reaction.
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نویسندگان مقاله | Sepide Kadivarian
Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Mosayeb Mosayeb
Infectious Diseases Research Center, Health Policy and Promotion Institute, Kermanshah, Iran


| Sara Kooti
Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Shirin Dashtbin
Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Somayeh Hosseinabadi
Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Ramin Abiri
Fertility and Infertility Research Center, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Amirhooshang Alvand
Medical Technology Research Center, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/5139
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