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Iranian Journal of Microbiology، جلد ۱۷، شماره ۵، صفحات ۸۳۵-۸۴۰
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عنوان انگلیسی Investigating the correlation between oncogenic HPV, sexually transmitted disease, and vaginal microbiota in patients with normal Pap smear
چکیده انگلیسی مقاله Background and Objectives: This study investigated the correlation between high-risk (HR) human papillomavirus (HPV), sexually transmitted disease (STD), and vaginal microbiota in patients with a normal Pap smear. Materials and Methods: For women who were referred for their routine cervical cancer screening, in addition to co-testing, some samples were taken from the vaginal and cervical environment to check the presence of the most common STD pathogens. The diagnosis of the organisms was done by means of PCR and microbial cultures. Results: HR HPV was detected in 67 women, and STD was positive in 80% of them, while in HR HPV negative women, this was 67%. The HPV positive group reported a significantly higher rate of STD history (92% vs. 82%) and frequency of intercourse weekly (86% vs. 3.96%) (p<0.05). Lactobacilli, streptococcus, and staphylococcus concentrations were significantly lower in the HPV positive group compared to the HPV negative group (p<0.007; OR = 4.17). Ureaplasma urealyticum and Ureaplasma parvum were significantly (p<0.001) more prevalent in the HPV positive group compared to the HPV negative group. Conclusion: This study showed that the existence of other STDs and the composition of the vaginal and cervical microbiome play an important role in either the clearance or the progression of high-risk HPV.
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نویسندگان مقاله | Farah Farzaneh
Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Khatereh Hekmatnia
Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Maryam Sadat Hosseini
Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Maliheh Arab
Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Maryam Talayeh
Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mahshid Vasef
Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Samaneh Yavari
Department of Obstetrics and Gynecology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Hossein Keyvani
Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/5630
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