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Iranian Journal of Microbiology، جلد ۱۷، شماره ۵، صفحات ۸۴۸-۸۵۳
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عنوان انگلیسی Investigation of the antifungal activity of panobinostat, tamoxifen, and miltefosine alone and in combination with some conventional antifungal drugs against fluconazole-resistant Candida species
چکیده انگلیسی مقاله Background and Objectives: The increasing incidence of antifungal-resistant Candida infections, particularly among cancer patients, emphasizes the urgency of exploring alternative therapeutic strategies. This study aimed to assess the in vitro antifungal efficacy of three anticancer agents—tamoxifen, panobinostat, and miltefosine—both individually and in combination with the antifungals fluconazole and itraconazole, against fluconazole-resistant Candida strains. Materials and Methods: A total of 21 clinical Candida isolates (C. albicans, C. parapsilosis, C. glabrata, C. tropicalis, and C. auris) were evaluated. Antifungal susceptibility testing was conducted following the microdilution protocol outlined by CLSI. Results: The combination of panobinostat with fluconazole exhibited full synergistic activity against C. albicans and C. tropicalis. Conversely, antagonistic effects were observed with C. parapsilosis and C. glabrata, while C. auris displayed an indifferent response. Panobinostat paired with itraconazole showed synergy exclusively against C. albicans. Similarly, miltefosine combined with itraconazole demonstrated synergism with C. albicans, but no interaction was found with fluconazole. Tamoxifen in conjunction with itraconazole revealed a synergistic response against C. albicans, antagonism with C. tropicalis, and indifference with other species. Conclusion: Certain combinations of antifungals and anticancer agents could potentiate antifungal activity against resistant Candida isolates. Therefore, precise species-level identification is vital for tailoring effective combination therapies, particularly in immunocompromised individuals.
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نویسندگان مقاله | Fatemeh Amirzadeh-Ghasemi
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Roshanak Daie Ghazvini
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Sadegh Khodavaisy
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Seyed Jamal Hashemi
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Ali Ahmadi
Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Pegah Ardi
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Mahdi Abastabar
Department of Medical Mycology and Parasitology, Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran


| Davoud Roostaei
Department of Pharmacology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran


| Zahra Rafat
Department of Medical Parasitology and Mycology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/5309
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