این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۹، شماره ۴، صفحات ۳۶۵-۳۷۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Dysregulated Expression of miR-222 and miR-15a in Transfusion-Dependent Thalassemia: Associations with Torque Teno Virus and Cytomegalovirus Infections
چکیده انگلیسی مقاله Background: Beta-thalassemia is a hereditary blood disorder characterized by reduced synthesis of the beta-globin chain. MicroRNAs (miRs) are small RNA molecules that regulate gene expression and have been implicated in beta-thalassemia. To explore dysregulated miR-222 and miR-15a expression in transfusion-dependent beta-thalassemia and assess their potential associations with Torque Teno Virus and cytomegalovirus infections. Materials and Methods: This study included 57 TDT patients registered at the Thalassemia Clinic affiliated with the Hematology Research Center, Shiraz, Iran. The expression levels of miR-222 and miR-15a were analyzed using the real-time SYBR Green PCR method. TTV and CMV infections were detected by analyzing the presence of their genomic DNA using an in-house semi-nested PCR protocol. Results: The expression level of miR-222 was significantly up-regulated (47.5-fold, P≤0.001) in TDT patients compared to healthy controls. However, the expression of miR-15a in TDT patients was slightly decreased compared to healthy controls, but the difference was not statistically significant (P=0.193). TTV infection was observed in 21.1% of TDT patients, while CMV infection was detected in 5.2% of the patients. Although miR-222 and miR-15a gene expression levels were higher in TTV-positive patients compared to TTV-negative patients, the differences were not statistically significant (P=0.926 and P=0.243, respectively). Conclusion: MiR-222 was up-regulated in TDT patients, but miR-15a did not show a significant difference. TTV and CMV infections were detected, but their association with miR expression was not significant, possibly due to the small sample size. Larger studies are needed for a more comprehensive evaluation.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Mahdiyar Iravani Saadi
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Nasrin Noshadi
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Fakhroddin Hosseini
Hematology, Oncology, and Bone Marrow Transplantation Department, Shiraz University of Medical Sciences, Shiraz, Iran


| Soodabeh Zare
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Ramin Yaghoobi
Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Zahed Karimi
1) Department of Hematology,Oncology, and Bone Marrow Transplantation, Shiraz Unversity of Medical Sciences, Shiraz, Iran 2) Hormozgan University of Medical Sciences, Bandar Abbas, Hormozgan, Iran


| Zahra Ghahramani
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Mani Ramzi
Shiraz University of Medical Sciences
نشانی اینترنتی https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/2249
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات