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International Journal of Organ Transplantation Medicine، جلد ۱۵، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی Urinary Tract Infections after Kidney Transplantation and their Associated Factors
چکیده انگلیسی مقاله Background: Many of the patients undergoing kidney transplantation (KT) are prone to urinary tract infections (UTIs) due to reasons such as ureter manipulation and damage during surgery, prolonged insertion of urinary catheters, and developing neurogenic bladder. Despite notable progress in surgical techniques and immunosuppression methods after kidney transplantation, UTIs persist as an important conundrum in these patients, predisposing them to morbidities and mortality. Objective: Therefore, this study aimed to investigate the factors associated with UTIs in patients undergoing kidney transplantation. Methods: In this follow-up analysis, 69 patients receiving KT under the supervision of the nephrology clinic of Shahid Mostafa Khomeini Hospital of Ilam city, Iran, from 2016 to 2018 were followed up in terms of developing post-transplant UTIs. All patients were examined for underlying diseases, renal failure, post-transplant UTI and its frequency, asymptomatic or symptomatic UTI, post-UTI renal function, type of organism, and drug resistance. The data gathered were analyzed using the firth logistic regression by STATA software version 12. Results: In this study, the first signs of UTIs appeared within one-month post-transplantation in 15.4% of the patients and within 12 months in 42.3% of them. No drug resistance was observed in 50% of the patients. Recurrent UTIs after transplantation was noticed in 57.6%. During the follow-up, all patients experienced at least one symptomatic UTI, and 38.5% of them developed asymptomatic UTIs at least once. In addition, kidney function decreased in 38.5% of the patients developing UTIs, and this rate was 25% among those who had symptomatic infections and 60% in individuals experiencing both symptomatic and asymptomatic UTIs. In multivariate analysis, advanced age (OR= 1.07, 95% CI: 1.02-1.13, P= 0.01) and female gender (OR= 13.10, 95% CI: 2.75-64.74, P= 0.002) were identified as independent risk factors for UTIs, while vitamin D level (OR= 0.94, 95% CI: 0.89-1.00, P= 0.05) was found to be a protective factor for UTIs after KT. Conclusion: According to our results, the incidence of UTIs in patients receiving renal grafts was higher in women than in men. Vitamin D level was identified as a protective factor against post-transplant UTI. All patients undergoing KT experienced symptomatic UTIs at least once, 38.5% of whom also revealed a decrease in renal function. Therefore, it is recommended to educate health professionals regarding the early signs of UTIs and their risk factors so that effective preventive measures can be implemented to avoid UTIs, subsequent dysfunction of the transplanted kidney, and patient death.
کلیدواژه‌های انگلیسی مقاله Kidney transplantation,Urinary tract infections,Risk factors,Vitamin D
نویسندگان مقاله | Bahareh Ghiasi
Assistant Professor of Nephrology, School of Medicine, Shahid Mostafa Khomeini Hospital, Ilam University of Medical sciences


| Maryam kheiry
Assistant Professor of physiology, Non-Communicable Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran.


| Saeed Shafieian
Non-Communicable Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran.


| Hossein Seidkhani
Assistant Professor of Bioinformatics, Department of Biostatistics, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran,


| Aliashraf Mozafari
Assistant Professor of Epidemiology, Department of Epidemiology, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran,
نشانی اینترنتی https://www.ijotm.com/ojs/index.php/IJOTM/article/view/1155
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi) 10.61882/ijotm.2024.15.1155
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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