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International Journal of Organ Transplantation Medicine، جلد ۱۵، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی Phospholipase A2 Receptor-Positive Membranous Nephropathy Associated with Polycythemia Presenting with Recurrent Venous Thrombosis
چکیده انگلیسی مقاله Background: Nephrotic syndrome with concomitant polycythemia is exceedingly rare, and its association with phospholipase A2 receptor (PLA2R)-positive membranous nephropathy is even more uncommon. Case Presentation: We report the case of a 29-year-old male who presented with recurrent venous thromboembolic events, including pulmonary embolism and renal vein thrombosis, and was subsequently found to have PLA2Rpositive membranous nephropathy with secondary polycythemia. Despite anticoagulation and immunosuppressive therapy, the patient continued to have recurrent thrombotic episodes and persistent proteinuria, ultimately requiring escalation to a modified Ponticelli regimen. This case underscores several important learning points. First, polycythemia as a manifestation of membranous nephropathy is an extremely rare phenomenon, with only a handful of cases described in the literature. Second, the presence of recurrent thromboembolism in young patients warrants careful evaluation for underlying glomerular disease, particularly when associated with heavy proteinuria and hypoalbuminemia. Third, the pathophysiological link between nephrotic syndrome and secondary polycythemia remains unclear, highlighting the need for ongoing clinical vigilance and further research. Conclusion: This report adds to the limited literature on the coexistence of membranous nephropathy and polycythemia, while emphasizing the importance of early recognition, combined immunosuppressive and anticoagulant strategies, and close follow-up to reduce morbidity from thrombotic complications.
کلیدواژه‌های انگلیسی مقاله Polycythemia,PLA2R antigen,Membranous nephropathy,Venous embolism
نویسندگان مقاله | Saurabh Puri
INSTITUTE OF LIVER & BILIARY SCIENCES, NEW DELHI


| Anand Naveen Thakur
INSTITUTE OF LIVER & BILIARY SCIENCES, NEW DELHI


| Vishal Batheja
INSTITUTE OF LIVER & BILIARY SCIENCES, NEW DELHI


| Bhavin Modasia
INSTITUTE OF LIVER & BILIARY SCIENCES


| Hari Shankar Meshram
INSTITUTE OF LIVER & BILIARY SCIENCES


| Chandani Bhagat
INSTITUTE OF LIVER & BILIARY SCIENCES


| Rajendra Prasad Mathur
INSTITUTE OF LIVER & BILIARY SCIENCES
نشانی اینترنتی https://www.ijotm.com/ojs/index.php/IJOTM/article/view/1168
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کد مقاله (doi) 10.61882/ijotm.2024.15.1168
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Case Report
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