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Journal of Arthropod-Borne Diseases، جلد ۱۹، شماره ۱، صفحات ۱۷۶۰-۱۷۶۰
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عنوان انگلیسی Antimicrobials Resistance Profiling and Clonal Lineages of Staphylococcus aureus Isolated from Cockroaches in University-Affiliated Hospitals, 2023
چکیده انگلیسی مقاله Background: Cockroaches, recognized as mechanical vectors, play a crucial role in transmitting microbial pathogens. Staphylococcus aureus (S. aureus), particularly antibiotic-resistant strains, poses a significant threat as a nosocomial path­ogen. This study aimed to investigate the resistance profiles to gentamicin, vancomycin, and antiseptics in S. aureus strains isolated from cockroaches in hospitals affiliated with Babol University of Medical Sciences. Methods: In this cross-sectional study, 60 S. aureus strains were isolated from 376 cockroaches in three university-affiliated hospitals. Antibiotic susceptibility to gentamicin and vancomycin was tested by disk diffusion and agar dilution. PCR was used to detect resistance and antiseptic genes, and MLVA typing determined the genetic relatedness of resistant isolates. Results: Among the 60 bacterial isolates, 46.7% (28) displayed resistance to gentamicin. The frequencies of aminogly­coside resistance coding genes (AMEs) for the aac(6')-Ie+aph(2″), ant(4')-Ia, aph(3')-IIIa and ant(6)-Ia genes were 64.3%, 42.8%, 17.8%, and 46.4%, respectively. Only 3.3% (2 isolates) exhibited vancomycin resistance, with one isolate (1.7%) carrying the vanA gene. The frequencies of genes encoding the antiseptic resistance genes qacA/B, qacC, qacD, psmA, sasX, and smr were 5%, 20%, 18.3%, 26.4%, 1.2%, and 31.7%, respectively. Analysis of agr gene types showed that agr type I was the most prevalent. In addition, the multiple-locus variable number tandem-repeat analysis (MLVA) identified 29 unique type sequences among the identified antibiotic-resistant isolates. Conclusion: The high genetic diversity among antibiotic-resistant S. aureus isolates, as revealed by MLVA, underscores the importance of controlling hospital cockroach populations to curb the spread of antibiotic resistance.
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نویسندگان مقاله | Mohsen Karami
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol Univer-sity of Medical Sciences, Babol, Iran


| Mehdi Safari
Student Research Committee, Babol University of Medical Sciences, Babol, Iran


| Yasin Saberi
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol Univer-sity of Medical Sciences, Babol, Iran


| Seyedeh Zohre Mirbagheri
1Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol Univer-sity of Medical Sciences, Babol, Iran, Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran


| Mehrdad Halaji
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol Univer-sity of Medical Sciences, Babol, Iran


| Jalal Jafarzadeh
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol Univer-sity of Medical Sciences, Babol, Iran


| Abazar Pournajaf
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol Univer-sity of Medical Sciences, Babol, Iran
نشانی اینترنتی https://jad.tums.ac.ir/index.php/jad/article/view/1760
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