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Journal of Nanostructures، جلد ۱۶، شماره ۱، صفحات ۵۴-۶۲
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عنوان انگلیسی Role of Silver Nanoparticles (Ag NPs) as Antimicrobial Potential on Biofilm Formation of Multidrug-Resistant (MDR) Bacteria Isolated from Different Sources
چکیده انگلیسی مقاله Because biofilms greatly boost human defenses and antibiotic tolerance, biofilm-associated illnesses brought on by multidrug-resistant (MDR) bacteria pose a serious danger to world health. Because of their broad-spectrum activity and capacity to change biofilm architecture, silver nanoparticles (AgNPs) have become a promising alternative to conventional antimicrobials. The purpose of this study was to assess chemically produced AgNPs’ antibacterial and antibiofilm effectiveness against MDR bacterial isolates derived from various clinical and environmental sources. Over the course of three months, from June to September 2024, one hundred isolated samples from various patient sources, ages ranging from 10 to 65, were gathered. Antimicrobial susceptibility testing was done on clinical isolates of P. aeruginosa. Bacteria were classified as MDR or XDR based on the Multiple Antibiotic Resistance (MAR) index. AGNPs’ minimum inhibitory concentrations (MIC) were established. AGNPs were described using both scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Examining the impact of AGNPs on biofilm development as a virulence factor allowed researchers to better understand their mode of action. The distribution of clinical samples by type of microorganism revealed that 37 (37.0%) isolates were K. pneumoniae. Twelve (12%) isolates were S. mutans, 22 (22.0%) isolates were Acinobacter spp., and 29 (29.0%) isolates were Pseudomonas aeruginosa. However, the distribution of microbe types in urine, wounds, burns, and blood by source of infection revealed that they were 45 (45%), 32 (32%), 17 (17%), and 6 (6%), respectively. All 100 examined isolates exhibited resistance patterns, and all were MDR. Biofilm development was significantly inhibited by AGNPs. After the bacteria were treated with silver nanoparticles, the percentage of biofilm development of the strong formation bacteria dropped from 45 (45.0%) to 6 (6.0%). Against a variety of MDR bacteria, AgNPs demonstrate strong antibacterial and antibiofilm activity, underscoring their potential as supplemental or substitute treatments for managing infections linked to biofilms. To convert these results into practical uses, more in vivo research and toxicity evaluations are necessary.
کلیدواژه‌های انگلیسی مقاله Silver Nanoparticles (Ag NPs),Biofilm Formation,Multidrug-Resistant (MDR) Bacteria
نویسندگان مقاله Fatin Ali Al-Clalabi |
Department of Biology, College of Education of Pure Science, University of Diyala, Iraq

A. S. Muthanna Al-Mahdawi |
Department of Biotechnology, College of Sciences, University of Diyala, Iraq

نشانی اینترنتی https://jns.kashanu.ac.ir/article_115143_d8ea0481566dbcc50096ae96b6b80dc0.pdf
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