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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۵، صفحات ۶۶۳-۶۷۲
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عنوان انگلیسی Probiotic treatment differentially affects the behavioral and electrophysiological aspects in ethanol exposed animals
چکیده انگلیسی مقاله Objective(s): Harmful effects of alcohol on brain function including cognitive phenomena are well known. Damage to gut microbiota is linked to neurological disorders. Evidence indicates that intestinal flora can be strengthened by probiotic bacteria. In this study, we evaluated the effect of probiotics administration on LTP induction in rats receiving ethanol.Materials and Methods: To assess if probiotic treatment influences toxic effect of ethanol, vehicle (CON) and probiotic treated (CON+PRO) control rats, and chronic ethanol (CE) exposed and CE probiotic treated (CE+PRO) animals were entered into the experiments. Shuttle box test and in vivo electrophysiological recordings were accomplished to evaluate memory and hippocampal baseline filed excitatory postsynaptic potentials (fEPSPs) and long term potentiation (LTP), respectively.  Results: Ethanol impaired memory in the CE rats. It also diminished the slope size of fEPSPs and prevented LTP induction. While the probiotic supplementation improved memory in the CE+PRO rats, it did not influence synaptic transmission in these animals. Conclusion: Conclusively, behavioral but not electrophysiological aspect of cognition is sensitive to probiotic treatment in the ethanol exposed animals.
کلیدواژه‌های انگلیسی مقاله Ethanol, LTP, Memory, Probiotics, Rat
نویسندگان مقاله | Amir Hosein Hadidi Zavareh
Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, Iran


| Ramin Haji Khani
Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, Iran


| Bahareh Pakpour
Department of Biology, Faculty of Sciences Central Tehran Branch, Islamic Azad University, Tehran, Iran


| Masoud Soheili
Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran


| Mahmoud Salami
Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_14925.html
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