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Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۵، صفحات ۴۹۵-۵۰۱
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عنوان انگلیسی The role of nitric oxide in the protective action of remote ischemic per-conditioning against ischemia/reperfusion-induced acute renal failure in rat
چکیده انگلیسی مقاله Objective(s): We investigated the role of nitric oxide (NO) in the protective effects of remote ischemic per-conditioning (rIPerC) on renal ischemia/reperfusion (I/R) injury in male rats.
Materials and Methods: I/R treatment consisted of 45 min bilateral renal artery ischemia and 24 hr reperfusion interval. rIPerC was performed using four cycles of 2 min occlusions of the left femoral artery and 3 min reperfusion at the beginning of renal ischemia. The animals were given normal saline (vehicle), NG-nitro-L-arginine methyl ester (L-NAME) or L-arginine. Following the reperfusion period, renal functional- and oxidative stress- parameters, as well as histopathological changes were assessed.
Results: In comparison with the sham group, I/R resulted in renal dysfunction, as indicated by significantly lower creatinine clearance and higher fractional excretion of sodium. This went along with decreased glutathione peroxidase (GPX) and catalase (CAT) activity in the I/R group, increased malondialdehyde (MDA) contents and histological damages. In comparison with the I/R group, the rIPerC group displayed improved renal function, increased activity of GPX and CAT enzymes, and decreased MDA level. However, these effects were abrogated by L-NAME injection and augmented by L-arginine treatment.
Conclusion: According to the results, the functional and structural consequences of rIPerC against I/R-induced kidney dysfunction, which is associated with reduction of lipid peroxidation and intensification of anti-oxidant systems, is partially dependent on NO production.
کلیدواژه‌های انگلیسی مقاله Kidney, Nitric oxide, Oxidative stress, Remote ischemic per-conditioning, Reperfusion injury
نویسندگان مقاله | Firouzeh Gholampour
Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran


| Leila Khangah
Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran


| Jafar Vatanparast
Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran


| Hamid Reza Karbalaei-Heidari
Department of Biology, College of Science, Shiraz University, Shiraz, Iran


| Seyed Molammad Owji
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Aminollah Bahaoddini
Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_10539.html
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