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International Journal of Radiation Research، جلد ۲۳، شماره ۴، صفحات ۸۳۳-۸۳۸
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چکیده فارسی مقاله
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عنوان انگلیسی Correlation between clinical, CT features and EGFR gene in minimally invasive adenocarcinoma
چکیده انگلیسی مقاله
Background: To analyze the correlation between epidermal growth factor receptor (EGFR) gene mutations and clinical as well as computed tomography (CT) signs in minimally invasive adenocarcinoma (MIA). Materials and Methods: A total of 118 patients with MIA treated at the Department of Thoracic Surgery, Tangshan Gongren Hospital, from December 2018 to December 2021 were included in this study. Patients were categorized into two groups based on their Epidermal Growth Factor Receptor(EGFR) mutation status: a mutation group and a wild-type group. Differences in clinical and CT features between the two groups were recorded and statistically analyzed. Results: Among the 118 patients, 69 were in the mutation group, while 49 were in the wild-type group. No significant differences were observed in gender, smoking history, age, mean nodule diameter, peripheral emphysema, air bronchogram, lobulation sign, pleural indentation sign, morphology, tumor-lung interface, peripheral fibrosis, and density between the two groups (P>0.05). However, significant differences were noted in the spiculation sign, vacuole sign, and vascular convergence sign between the groups (P<0.05). Logistic regression analysis identified the vacuole sign with an odds ratio (OR) of 0.410 (P>0.05) and the spiculation sign and vascular convergence sign with ORs of 1.498 and 2.262, respectively (P<0.05), as independent risk factors for predicting EGFR mutations. The areas under the ROC curves (AUC) for the spiculation sign and vascular convergence sign were 0.634 and 0.735, respectively, in distinguishing EGFR gene mutations in MIA. Conclusion: CT imaging demonstrated that MIA patients presenting with spiculation, vacuole, and vascular convergence signs had a higher likelihood of EGFR gene mutations. Among these, the spiculation and vascular convergence signs are critical, independent risk factors for predicting EGFR gene mutations in MIA patients.
کلیدواژه‌های انگلیسی مقاله Lung adenocarcinoma, CT signs, epidermal growth factor receptor, tomography, X-ray computed.
نویسندگان مقاله | L.P. Zhou
Department of Function, The Fifth Hospital of Tangshan (CT/DR Room), Tangshan, China


| L.M. Chang
Department of Medical Imaging, Tangshan Gongren Hospital, Tangshan, China


| H. Zhao
Department of Medical Imaging, Tangshan Gongren Hospital, Tangshan, China


| X.Y. Yang
Department of Medical Imaging, Tangshan Gongren Hospital, Tangshan, China


| L.L. Shi
Department of Radiology, Tangshan Maternal and Child Health Hospital, Tangshan, 063000, China
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-1-1404&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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