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Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۱۲، صفحات ۱۶۲۰-۱۶۳۰
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عنوان انگلیسی Advances in cancer immunotherapy: Strategies and innovations strategies for adoptive immunotherapy of cancer
چکیده انگلیسی مقاله Cancer immunotherapy has emerged as a transformative approach in oncology, offering alternatives beyond traditional treatments. This narrative review focuses on major innovations, including adoptive cell therapy (ACT), chimeric antigen receptor T-cells (CAR-T), T-cell receptor (TCR) engineering, monoclonal antibodies (mAbs), bispecific antibodies (BsAbs), and immune checkpoint inhibitors (ICIs). The central aim of this article is to analyze how these technologies improve antitumor responses and help overcome resistance in hematologic and solid tumors. This narrative review combines the latest findings from clinical and preclinical studies to highlight therapeutic potentials and challenges. Key observations include the clinical success of CAR-T cells in treating blood cancers, the expanding application of ICIs in solid tumors, and the evolving structure-function relationship of BsAbs in recruiting immune effectors. This paper concludes by evaluating the current limitations of these immunotherapeutic strategies and discusses future directions for integrating them into personalized cancer therapy.
کلیدواژه‌های انگلیسی مقاله Adoptive cell transfer, Bispecific antibodies, Chimeric antigen receptor T-cells, Immune checkpoint inhibitors, Immunotherapy Neoplasm, Tumor Microenvironment
نویسندگان مقاله | Leila Moeinzadeh
Aryogen Pharmed Biopharmaceutical Research Center, Alborz University of Medical Science, Karaj, Iran


| Mohammad Reza Mahmoudian-Sani
Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Daryush Purrahman
Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Fatemeh Azghadi
Student Research Committee, School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran


| Mohamad amin Darbandi
Clinical Research Development Unit, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_26845.html
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نوع مقاله منتشر شده Review Article
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