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Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۱۲، صفحات ۱۶۵۶-۱۶۶۶
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Plasma exosomal miR-142-3p induced by acupuncture protects against heart injury in rats with myocardial infarction by targeting Cofilin 2
چکیده انگلیسی مقاله Objective(s): The protective effects of acupuncture on myocardial injury have been identified in clinical trials. However, there is still a lack of comprehensive understanding of its fundamental mechanism. This research aimed to clarify the roles of plasma exosomes in the cardioprotection of acupuncture.Materials and Methods: Myocardial infarcted rats were divided into control group, acupuncture group, and acupuncture plus GW4869 group. The rats without the performance of a myocardial infarction were divided into a sham group. Acupuncture was performed at bilateral PC6. Results: The results showed that the effects of acupuncture on increasing the thickness of the left ventricular infarct wall and inhibiting apoptosis of the damaged heart tissue were significantly reversed by GW4869. Among the five miRNAs of plasma exosomes increased by acupuncture, miR-142-3p was the unique miRNA up-regulated in myocardial tissue. Overexpressing miR-142-3p retarded oxidative damage of H9c2 by anti-apoptosis. miR-142-3p directly bound to and suppressed the expression of Cofilin 2 (CFL2). In vivo CFL2 expression was down-regulated by acupuncture and up-regulated by GW4869.Conclusion: Our results suggest that plasma exosomes transfer cardio-protective signals of acupuncture to the injured heart and confer cardioprotective effects, and miR-142-3p emerges as a prominent exosomal miRNA in the inhibition of myocardial apoptosis by targeting CFL2.
کلیدواژه‌های انگلیسی مقاله Acupuncture, Cofilin 2, Exosomes, microRNAs, Myocardial infarction
نویسندگان مقاله | Yue Zhao
Department of Histoembryology, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China


| Ying Wang
Department of Chemistry, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China


| Chunrong Guo
School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China


| Qiyu Sun
Department of Chemistry, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China


| Jinxia Mi
Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China


| Pingping Lu
Department of Anatomy, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China


| Shuijin Shao
Department of Anatomy, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China


| Rong Lu
School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China


| Haidong Guo
School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China


| Qiangli Wang
Department of Histoembryology, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
نشانی اینترنتی https://ijbms.mums.ac.ir/article_26552.html
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