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Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۱۲، صفحات ۱۷۴۳-۱۷۴۸
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عنوان انگلیسی Rhein attenuates obesity-related glomerulopathy by inhibiting the P2X7R/NLRP3 inflammasome pathway and protecting podocytes
چکیده انگلیسی مقاله Objective(s): To investigate the renoprotective effects of Rhein in obesity-related glomerulopathy (ORG) by inhibiting the P2X7 receptor (P2X7R)/NOD-like receptor protein 3 (NLRP3) inflammasome pathway.Materials and Methods: ORG was induced in C57BL/6J mice with a high-fat diet (HFD) for 10 weeks, fol-lowed by oral Rhein treatment (70 or 300 mg/kg/day) for 10 weeks. Renal function, histology, and podocyte injury were assessed. In vitro, leptin-induced podocyte injury was treated with Rhein or P2X7R antagonists (KN-62 or A-438079). P2X7R/NLRP3 activation, inflammation, and oxidative stress were evaluated.Results: HFD-induced weight gain, dyslipidemia, renal dysfunction, glomerular hypertrophy, and podocyte injury. Rhein reduced serum triglycerides (TG) and total cholesterol (TC), lowered blood urea nitrogen (BUN), improved urinary protein excretion, and alleviated histological damage. Rhein inhibited P2X7R and NLRP3 activation, down-regulated caspase-1, interleukin (IL)-1β, and IL-18, and restored podocyte markers (Nephrin, Podocin). In vitro, Rhein mitigated leptin-induced podocyte injury and inflammasome activation.Conclusion: Rhein protects against ORG by suppressing the P2X7R/NLRP3 pathway, reducing inflammation and oxidative stress, and preserving podocyte integrity, highlighting its therapeutic potential.
کلیدواژه‌های انگلیسی مقاله Inflammation, Leptin, NLRP3 inflammasome, Obesity-related- glomerulopathy, P2X7 receptor, Podocyte, Rhein
نویسندگان مقاله | Lifang Wei
Department of Nephrology, The Third People’s Hospital Affiliated to Fujian Univer-sity of Traditional Chinese Medicine, Fuzhou, Fujian, China


| Jinwen Zhang
State Key Laboratory of Infectious Disease Vaccine Development, Xiang An Bio-medicine Laboratory & State Key Laboratory of Molecular Vaccinology and Molecu-lar Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China


| Liangding Dou
State Key Laboratory of Infectious Disease Vaccine Development, Xiang An Bio-medicine Laboratory & State Key Laboratory of Molecular Vaccinology and Molecu-lar Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China


| Xiaoxin Wu
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang, China


| Minmin Xu
Department of Nephrology, The Third People’s Hospital Affiliated to Fujian Univer-sity of Traditional Chinese Medicine, Fuzhou, Fujian, China


| Jinxia Ye
Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fuzhou, Fujian, China


| Yanyan Yang
Innovation and Transformation Center, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China


| Yongxing Zhang
State Key Laboratory of Infectious Disease Vaccine Development, Xiang An Bio-medicine Laboratory & State Key Laboratory of Molecular Vaccinology and Molecu-lar Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China


| Shaojian Xiao
The Third People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China
نشانی اینترنتی https://ijbms.mums.ac.ir/article_26900.html
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