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Iranian Journal of Public Health، جلد ۵۴، شماره ۱۰، صفحات ۲۲۱۲-۲۲۲۲
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عنوان انگلیسی Causal Relationship between Immune Cells and Postpartum Depression: A Bidirectional Two-Sample Mendelian Randomization Study
چکیده انگلیسی مقاله Background: Postpartum depression (PPD) is influenced by immune factors, particularly immune cells. The causal relationship between these cells and PPD is unclear. Methods: Bidirectional two-sample Mendelian randomization (TSMR) analysis was performed to determine the causal relationship between immune cell characteristics and PPD. The main analysis method used was the inverse variance weighted (IVW) method. To ensure the robustness, heterogeneity, and horizontal pleiotropy of the results, a comprehensive sensitivity analysis was conducted. Results: Overall, 28 immune cell phenotypes were identified as causally related to the onset of PPD. Most of them were distributed in the B cell group and the Treg cell group. Further analysis revealed that 13 types of immune cells had a promoting effect on PPD, whereas 15 types of immune cells had a protective effect. In addition, the incidence of PPD was found to be causally related to CD62L on granulocyte [IVW: OR (95%): 1.183 (1.037 to 1.348), P = 0.012]. Conclusion: The study unveils the causal link between immune cells and susceptibility to postpartum depression from a genetic standpoint, providing new directions for drug development and precision medicine for PPD treatment.
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نویسندگان مقاله | Yingjia Zhu
Department of Gynecology, Hangzhou Women’s Hospital, Hangzhou, Zhejiang, 310000, China


| Feng Cheng
Department of Orthopedics, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310000, China


| WenHui Wang
Department of Pathology, Hangzhou Women’s Hospital, Hangzhou, Zhejiang, 310000, China


| XinYun Yang
Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China


| Mingjie He
Department of General Practice, Yiqiao Community Health Service Center, Hangzhou, Zhejiang 310000, China


| Zhiyin Zhang
Department of Gynecology, Hangzhou Women’s Hospital, Hangzhou, Zhejiang, 310000, China


| LinLing Zhu
Department of Gynecology, Hangzhou Women’s Hospital, Hangzhou, Zhejiang, 310000, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/36527
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