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Acta Medica Iranica، جلد ۶۳، شماره ۴، صفحات ۲۳۱-۲۳۶
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عنوان انگلیسی Blood Indoxyl Sulfate and TGF-β1 Protein and mRNA Levels in Chronic Kidney Disease: Updated Insights
چکیده انگلیسی مقاله Chronic kidney disease (CKD) is characterized by systemic inflammation and the accumulation of uremic toxins such as indoxyl sulfate (IS), which induces fibrogenic signaling via transforming growth factor-beta 1 (TGF-β1). Forty CKD patients and ten healthy controls were enrolled. IS was measured by HPLC, TGF-β1 protein by ELISA, and TGF-β1 mRNA by RT-qPCR in PBMCs. IS and TGF-β1 mRNA levels increased significantly with CKD stage, particularly in stages 3 and 4. TGF-β1 mRNA correlated with IS levels (R=0.4, P<0.01), while TGF-β1 protein levels were associated with platelet count (R=0.817, P<0.001). TGF-β1 mRNA in PBMCs may serve as an early biomarker of CKD-related fibrosis. IS is a key uremic toxin influencing fibrogenic gene expression.
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نویسندگان مقاله | Farhad Nazarinasi
Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Siavash Gerayeshnejad
Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Nasrin Dashti
Department of Laboratory Science, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.


| Khosrow Rahbar
Department of Nephrology and Urology, Mehrad Hospital, Tehran, Iran.
نشانی اینترنتی https://acta.tums.ac.ir/index.php/acta/article/view/11674
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