Aims The present study aimed to assess the efficacy of training intervention on the prevalence rate of needlestick and sharp injuries among healthcare workers.
Materials & Methods This before-and-after interventional study was conducted on 1,286 healthcare workers in a tertiary-care university-affiliated hospital. Data were collected in two phases: a 6-month pre-intervention period and a 6-month post-intervention period. During this time, a large educational poster, based on NIOSH/CDC guidelines, was installed at key hospital entry and exit points. The primary outcome variable was the incidence of needlestick injuries (NSIs), sharp injuries, and splash exposures, as reported through the hospital’s standardized incident reporting form. Demographic and occupational variables, including age, gender, job title, work experience, department, and shift, were also recorded. Data were analyzed using descriptive statistics, Chi-square tests, and logistic regression to examine the association between exposure rates and participant characteristics. A p-value less than 0.05 was considered statistically significant.

Findings In the first six months, 116 healthcare workers experienced NSIs; accordingly, the incidence of NSIs among trial participants before the trial intervention was 9.02%. During the second six months, 101 healthcare workers experienced NSIs, and the incidence among trial participants after the trial intervention was 7.85% (OR=0.74; CI: 0.56–0.97; P=0.03). There were no significant differences in study variables between the two groups before and after the intervention.
Conclusion Designing education-based interventions is a fundamental method for controlling and reducing the incidence of needlestick, sharp injuries, and infectious splashes.