| چکیده انگلیسی مقاله |
Introduction: Childhood obesity is associated with increased inflammation and metabolic disorders, such as elevated tumor necrosis factor-alpha (TNF-α) levels and adverse changes in the lipid profile. Aerobic exercise, as a non-pharmacological intervention, may help improve these indicators. This meta-analysis was conducted to examine the effects of aerobic exercise on the lipid profile and TNF-α levels in overweight and obese children and adolescents.
Materials & Methods: A comprehensive search of databases such as PubMed, Web of Science, Scopus, Magiran, Noor Mags, Google Scholar, and SID was conducted to review all articles published from inception to June 29, 2025. In this systematic review, types of aerobic exercise such as running, cycling, treadmill, and group exercise were examined. To understand the effect of aerobic exercise on blood lipids (such as HDL, LDL, total cholesterol, and triglycerides) and TNF-α levels, data on children and adolescents aged 6 to 18 years who were overweight or obese were analyzed with CMA version 2 software, and weight mean difference (WMD) and 95% confidence intervals were calculated.
Results: The meta-analysis comprised 25 studies, including 29 aerobic exercise interventions, with a total of 840 overweight and obese children and adolescents (both genders). The findings indicated that aerobic exercise was correlated with a notable increase in HDL (P = 0.026, WMD = 2.740 mg/dl, 95% CI: 0.323 to 5.158) and substantial decreases in TNF-α (P = 0.005, WMD = -0.495 pg/ml, 95% CI: -0.840 to -0.150), LDL (P = 0.001, WMD = -8.795 mg/dl, 95% CI: -12.871 to -4.718), TC (P = 0.002, WMD = -11.287 mg/dl, 95% CI: -17.599 to -4.976), and TG (P = 0.001, WMD = -23.72 mg/dl, 95% CI: -34.419 to -13.030) in comparison to the control groups.
Conclusion: Aerobic exercise improves blood lipids and reduces TNF-α levels in overweight or obese children and adolescents. This effect has been seen most in programs that last about 4 to 20 weeks and are performed two to four times a week at moderate to vigorous intensity. In short, aerobic exercise is a simple and safe way to improve health and metabolism in this age group.
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| نویسندگان مقاله |
امید ظفرمند | Omid Zafarmand
Dept of Physical Education and Sports Sciences, School of Humanities, University of Yasouj, Yasouj, Iran
گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه یاسوج، یاسوج، ایران
فاطمه کاظمی نسب | Fatemeh Kazeminasab
Dept of Physical Education and Sport Sciences, School of Humanities, University of Kashan, Kashan, Iran
گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه کاشان، کاشان، ایران
مهدی مقرنسی | Mehdi Mogharnasi
Dept of Sports Sciences, University of Birjand, Birjand, Iran
گروه علوم ورزشی، دانشکده علوم ورزشی، دانشگاه بیرجند، بیرجند، ایران
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