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Iranian Journal of Basic Medical Sciences، جلد ۲۹، شماره ۱، صفحات ۵۵-۶۴
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عنوان انگلیسی Enhancing clomipramine antidepressive effect using nanocomplexes via different routes of administration: A comparative study
چکیده انگلیسی مقاله Objective(s): Enhancing clomipramine anti-depressive effect using a nanoformulation and investigating its effect via different routes of administration (oral and intranasal) in a depression rat model. Polyelectrolytes nanocomplexes (NC) were prepared by an all-aqueous technique and were composed of different ratios of chitosan (CS) and gum arabic (GA). Materials and Methods: Ciprofloxacin (CPX) was administered orally to adult male Wistar albino rats at a dose of 50 mg/kg for 14 days to induce depression. Clomipramine HCl solution and the drug-loaded nano complexes (NC) were administrated for 14 days via the oral route (50 mg/kg) and intranasal route (500 µg/kg). Results: All the prepared drug-loaded nano-complexes (NC) were uniformly distributed (PDI ˂0.2), NC1 (composed of CS:GA 1:1) attained the smallest particle size (200.30 ± 26.07nm) and the most sustained release profile (Mean Release Time= 96.02± 8.36 min.) and has a spherical outline as detected by transmission electron microscope. Treatment with clomipramine-loaded NC via oral and intranasal routes elevated swimming time, serotonin (5-HT), excitatory amino acid transporter 2 (EAAT2) and Gamma-aminobutyric acid (GABA) brain contents, decreased brain content of malondialdehyde (MDA) and nitric oxide (NO), and ameliorated nuclear pyknosis and degeneration of neurons compared to CPX and clomipramine solution. Clomipramine-loaded NC via intranasal routes returned the brain content of 5-HT and EAAT 2 to its normal level and has effect superior than oral route.Conclusion: Clomipramine-loaded NC administered via intranasal route showed an enhanced effect and a higher antidepressant activity than the traditional oral route through alleviating CPX neurological toxicity.
کلیدواژه‌های انگلیسی مقاله Depression, Ciprofloxacin, clomipramine, nanocomplex, chitosan, gum arabic, GAPA/EAAT2
نویسندگان مقاله | Abeer Salama
Pharmacology Department, National Research Centre, El-Bohooth Street (P.O. 12622), Cairo, Egypt


| Rabab Kamel
Pharmaceutical Technology Department, National Research Centre, El-Bohooth Street, Cairo, Egypt


| Nourina N. Ghoneim
Egyptian Drug Authority, Cairo, Egypt


| Shereen S. Elshaer
Department of Biochemistry, Faculty of Pharmacy, Heliopolis University,Cairo,Egypt|Department of Biochemistry and Molecular Biology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt
نشانی اینترنتی https://ijbms.mums.ac.ir/article_27112.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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