این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۹، شماره ۱، صفحات ۱۳۸-۱۴۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The protective effect of resveratrol on lupus nephritis mice by up-regulating Sirt1
چکیده انگلیسی مقاله Objective(s): To investigate the therapeutic effect and protective mechanism of resveratrol (Res) on mice with lupus nephritis (LN).Materials and Methods: We used Res to intervene in MRL/lpr mice and employed biochemical techniques to assess kidney function, inflammation levels, and oxidative stress. We also evaluated changes in immune function and used immunohistochemistry to assess Sirt1 protein and mRNA expression.Results: Res improved the kidney function, alleviated proteinuria, and renal pathological damage in MRL/lpr mice. Res also ameliorated spleen weight and spleen index, and inhibited urinary protein/creatinine levels. Moreover, Res inhibited the expression of circulating inflammatory factors, oxidative stress levels, and kidney cell apoptosis in MRL/lpr mice. Res effectively promoted Sirt1 protein and mRNA expression in the kidneys of MRL/lpr mice. Conclusion: Res has a protective effect on MRL/lpr mice, and its mechanism may involve activation of the Sirt1 signaling pathway.
کلیدواژه‌های انگلیسی مقاله Apoptosis, Lupus nephritis, Oxidative stress, Resveratrol, SIRT1
نویسندگان مقاله | Yu Zhao
Department of Rheumatology, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, P.R. China|Department of Nephrology, Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang Province, P.R. China


| Yun Cai
Department of Nephrology, Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang Province, P.R. China


| Jie Chen
Department of Nephrology, Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang Province, P.R. China


| Yang Xu-yan
Department of Rheumatology, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, P.R. China
نشانی اینترنتی https://ijbms.mums.ac.ir/article_27107.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات