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Iranian Journal of Basic Medical Sciences، جلد ۲۹، شماره ۱، صفحات ۱۴۵-۱۵۴
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عنوان انگلیسی Comparative effects of estradiol and daidzein on the expression of endometrial cancer-related genes and histopathological parameters in the uterus of ovariectomized rats
چکیده انگلیسی مقاله Objective(s): This study compared the effects of daidzein (DZD) and 17-β-estradiol (E2) on uterine histopathology, expression of endometrial cancer-related genes, and anti-oxidant status in ovariectomized (OVX) rats.Materials and Methods: Thirty rats were divided into five groups (n=6): Sham, OVX, OVX+E2 (10 μg/kg/day), OVX+DZD (20 mg/kg/day), and DZD-only. After 50 days of treatment, uterine tissues were analyzed for histopathological changes, mRNA expression of ERα, ERβ, PTEN, EZH2, and Ki67, and oxidative stress markers (TAC, SOD, CAT, and MDA).Results: Ovariectomy induced endometrial atrophy, significantly downregulated the expression of all target genes (ERα, ERβ, PTEN, EZH2, and Ki67), decreased SOD and CAT activity and TAC level, and increased MDA. E2 treatment reversed these changes but induced hyperplastic effects. DZD administration significantly increased CAT and SOD activity and elevated ERβ and Ki67 expression compared with the OVX group. Crucially, DZD prevented uterine atrophy without inducing hyperplasia.Conclusion: DZD demonstrated a potentially beneficial effect by improving uterine anti-oxidant capacity and preventing atrophy, but without the hyperplastic changes associated with estradiol. These findings suggest that DZD may be a safer alternative for managing hypoestrogenic conditions, warranting further investigation.
کلیدواژه‌های انگلیسی مقاله Endometrial neoplasms, Estrogens, Ovariectomy, Oxidative stress, Phytoestrogens, Rats
نویسندگان مقاله | Vahid Setayesh
Department of Biochemistry, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran


| Asma Neisy
Department of Biochemistry, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran


| Maryam Niknam
Department of Biochemistry, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran


| Zahra Khoshdel
Department of Biochemistry, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran


| Farhad Koohpeyma
Research committee, Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Sanaz Alaee
Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran|Department of Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe, 030012, Kazakhstan


| Fatemeh Zal
Department of Biochemistry, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran|Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_27131.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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