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Cell Journal، جلد ۱۹، شماره ۲، صفحات ۲۶۹-۲۷۷
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عنوان انگلیسی Synthesis and Characterization of PMBN, As a Biocompatible Nano Polymer for Bio-Applications
چکیده انگلیسی مقاله Objective: PMBN, Poly [2-methacryloyloxyethyl phosphoryl choline (MPC)-co-n- buthyl methacrylate (BMA)-co-p-nitrophenyl- oxycrabonyl poly (ethylene glycol-methacrylate (MEONP)], as a biocompatible ter-polymer is a unique polymer with wide range of application from Drug Delivery Systems to Scaffolds and Biomedical Devices. In this research, monomer of p- nitrophenyl- oxycarbonyl poly (ethylene glycol) methacrylate (MEONP) was prepared for synthesizing the polymer. Next, the smart, water soluble and amphiphilic polymer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), nbutyl methacrylate (BMA) and MEONP units (PMBN polymer) was designed and prepared. These monomers show unique chemical and biological functions Materials and methods: In this experimental study, into two necked flask equipped with inlet-outlet Gas, MPC (4 mmol, 40% mol fraction), BMA (5 mmol, 50% mol fraction), and MEONP (1 mmol, 10% mol fraction) were dissolved at 20 ml of dry Ethanol. The characteristics of synthesized monomer and the polymer are discussed by using FT-IR (Fourier Transform Infrared Spectroscopy), H-NMR (Proton Nuclear Magnetic Resonance), DLS (Dynamic Light Scattering), GPC (Gel Permeation Chromatography), SEM (Scanning Electron Microscope) and TEM (Transmission Electron Microscope) analysis methods to characterize its structure well for the first time. To figure out its biocompatibility, polymer was treated by two different cell lines. Results: The FT-IR and H-NMR analysis confirm the synthesis of polymer. The size of polymer is around 40 nm with molecular weight of 52 kDa which are great for a Nano carrier. The microscopic analyses show that the polymer is Rod shaped. In addition to, this polymer shows no toxicity for cells individually. Conclusion: We report here, for the first time, the full properties of PMBN polymer. The size around of 40 nm with acceptable range of Zeta potential, -8.47, PDI: 0.1, and Rod shaped structure are great parameters for a Nano polymer for Nano Bio-applications. We are applying this polymer to design a new smart Nano carrier for treatment of Leukemia Stem Cells based on target drug delivery system as kind of bio-application.
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نویسندگان مقاله پوریا معتمد فتح | puria motamed fath


فاطمه یزدیان | fatemeh yazdian


رقیه جم جاه | rogayyeh jamjah


بهمن ابراهیمی حسین زاده | bahman ebrahimi hosseinzadeh


مایده رحیم نژاد | maede rahimnezhad


رضی صحراییان | razi sahraeian


اشرف السادات حاتمیان | ashrafalsadat hatamian


نشانی اینترنتی http://celljournal.org/journal/article/abstract/4119
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/16/article-16-367019.pdf
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