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Cell Journal، جلد ۱۹، شماره ۲، صفحات ۲۸۳-۲۹۱
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عنوان انگلیسی Methoxyamine Enhances 5-Fluorouracil-Induced Radiosensitization in Colon Cancer Cell Line HT29
چکیده انگلیسی مقاله Objective: The purpose of this study was to observe the effects of methoxyamine (Mx) on the cytotoxic effects and DNA damage caused by 5-fluorouoracil (5-FU), in combination with gamma-rays in human colon cancer cell line. Materials and methods: In this experimental study, HT29 cells were cultured as a monolayer and treated with different concentrations of 5-FU along with 1 mM Mx for 24 h. After this time, the cells were irradiated with 2 Gy gamma-ray radiations. After the treatments, DNA damage, cytotoxicity and viability were studied using alkaline comet, clonogenic survival and trypan blue dye exclusion assays, respectively. Results: Our results showed that cytotoxicity and DNA damage increased along with the increasing 5-FU concentration. Moreover, 1 mM Mx had no significant effect on the cytotoxicity and DNA damage by 5-FU; however, it increased the cytotoxic and genotoxic effect of different concentrations of 5-FU when used in combination with 2 Gy gamma-ray radiation. Conclusion: Our results indicated that Mx in combination with 5-FU enhanced the radiosensitivity of colon cancer cells.
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نویسندگان مقاله سمیده خویی | samideh khoei


رقیه پورعبدالهی | roghayeh poorabdollahi


احمد مستعار | ahmad mostaar


فریبرز فایقی | fariborz faeghi


نشانی اینترنتی http://celljournal.org/journal/article/abstract/4295
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/16/article-16-367021.pdf
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