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Cell Journal، جلد ۱۹، شماره ۱، صفحات ۱-۱۰
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عنوان انگلیسی Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy
چکیده انگلیسی مقاله Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous system (CNS) lesions that can lead to severe physical or cognitive disability as well as neurological defects. Although the etiology and pathogenesis of MS remains unclear, the present documents illustrate that the cause of MS is multifactorial and include genetic predisposition together with environmental factors such as exposure to infectious agents, vitamin deficiencies, and smoking. These agents are able to trigger a cascade of events in the immune system which lead to neuronal cell death accompanied by nerve demyelination and neuronal dysfunction. Conventional therapies for MS are based on the use of anti-inflammatory and immunomodulatory drugs, but these treatments are not able to stop the destruction of nerve tissue. Thus, other strategies such as stem cell transplantation have been proposed for the treatment of MS. Overall, it is important that neurologists be aware of current information regarding the pathogenesis, etiology, diagnostic criteria, and treatment of MS. Thus, this issue has been discussed according to recent available information.
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نویسندگان مقاله ناظم قاسمی | nazem ghasemi


شهناز رضوی | shahnaz razavi


الهام نیکزاد | elham nikzad


نشانی اینترنتی http://celljournal.org/journal/article/abstract/4867
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/16/article-16-367026.pdf
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زبان مقاله منتشر شده en
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