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Cell Journal، جلد ۱۹، شماره ۱، صفحات ۹۴-۱۰۱
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عنوان انگلیسی Comparative study on preventive effect of saffron carotenoids, crocin and crocetin, in NMU-induced breast cancer in rat
چکیده انگلیسی مقاله Background: Crocin (Cro) and crocetin (Crt) are two widely known saffron carotenoids, which exert anticancer effect by different mechanisms. Here, we investigated and compared the preventive effect of the mentioned components at different stages, initiation and promotion, of breast cancer induction in model animal. Materials and methods: In this experimental study, female Wistar albino rats were injected with three doses of N-methyl-N-nitrosourea (NMU). The preventive intervention was done in two stages of initiation and promotion. Thus, Cro/Crt was administered by gavage 20 days before or one week after the first dose of NMU injection, for prevention of initiation or promotion stages, respectively and continued each 3 days, up to the end of the experiment. Tumor appearance was checked by palpation and some parameters were determined after scarification. Results: Tumor volume, latency period, and tumor number were significantly decreased in the rat groups treated with both saffron carotenoids for prevention in both initiation and promotion stages. Tumor incidence was decreased from 77% due to NMU injection to 45% and 33%, in average, by Cro and Crt administration, respectively. In addition, enkephaline degrading aminopeptidase (EDA) was decreased significantly in the ovary of animals, however, its changes in the brain was not significant. Conclusion: Crt/Cro showed a significant protective effect against the NMU-induced breast cancer in rats. However, Crt was more effective than Cro and prevention at initiation stage was more effective.
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نویسندگان مقاله سیده زهرا بطحایی | s zahra bathaie


میثم سجادی | meysam sajjadi


نشانی اینترنتی http://celljournal.org/journal/article/abstract/3901
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