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Cell Journal، جلد ۱۹، شماره ۱، صفحات ۱۱۷-۱۲۶
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عنوان انگلیسی Adipose-Derived Mesenchymal Stem Cells for Treatment of Airway Injuries in A Patient after Long-Term Exposure to Sulfur Mustard
چکیده انگلیسی مقاله Objective: Sulfur mustard (SM) is a potent mutagenic agent that targets several organs, particularly lung tissue. Changes in morphological structure of the airway system are associated with chronic obstructive pulmonary deficiency following exposure to SM. Although numerous studies have demonstrated pathological effects of SM on respiratory organs, unfortunately there is no effective treatment to inhibit further respiratory injuries or induce repair in these patients. Due to the extensive progress and achievements in stem cell therapy, we have aimed to evaluate safety and potential efficacy of systemic mesenchymal stem cell (MSC) administration on a SM- exposed patient with chronic lung injuries. Materials and methods: In this clinical trial study, our patient received 100×106 cells every 20 days for 4 injections over a 2-month period. After each injection we evaluated the safety, pulmonary function tests (PFT), chronic obstructive pulmonary disease (COPD) Assessment Test (CAT), St. George's Respiratory Questionnaire (SGRQ), Borg Scale Dyspnea Assessment (BSDA), and 6 Minute Walk Test (6MWT). Results: There were no infusion toxicities or serious adverse events caused by MSC administration. Although there was no significant difference in PFTs, we found a significant improvement for 6MWT, as well as BSDA, SGRQ, and CAT scores after each injection. Conclusion: Systemic MSC administration appears to be safe in SM-exposed patients with moderate to severe injuries and provides a basis for subsequent cell therapy investigations in other patients with this disorder (Registration Number: IRCT2015110524890N1).
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله امیر نژاد مقدم | amir nejad moghaddam


سهیلا اژدری | soheila ajdari


عیسی طهماسب پور | eisa tahmasbpour


حسن گودرزی | hassan goodarzi


یونس پناهی | yunes panahi


مصطفی قانعی | mostafa ghanei


نشانی اینترنتی http://celljournal.org/journal/article/abstract/4874
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/16/article-16-367037.pdf
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زبان مقاله منتشر شده en
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