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Cell Journal، جلد ۱۸، شماره ۴، صفحات ۵۹۷-۶۰۸
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عنوان انگلیسی Indoleamine 2,3-Dioxygenase Is Dispensable for The Immunomodulatory Function of Stem Cells from Human Exfoliated Deciduous Teeth
چکیده انگلیسی مقاله Objective: In this study, we sought to better understand the immunoregulatory function of stem cells derived from human exfoliated deciduous teeth (SHED). We studied the role of the interferon gamma (IFN-γ)-indoleamine 2,3-dioxygenase (IDO)-axis in immunoregulation of SHED compared to bone marrow derived mesenchymal stem cells (BMMSCs) under the same conditions. Materials and methods: In this cross-sectional study, recently isolated human T cells were stimulated either by mitogen or inactivated allogeneic peripheral blood mononuclear cells (PBMCs). These T cells were subsequently co-cultured with, either SHED or BMMSCs in the presence or absence of 1-methyl-tryptophan (1-MT) or neutralizing antihuman- IFN-γ antibodies. In all co-cultures we evaluated lymphocyte activation as well as IDO activity. Results: SHED, similar to conventional BMMSCs, had anti-proliferative effects on stimulated T cells and reduced their cytokine production. This property of SHED and BMMSCs was changed by IFN-γ neutralization. We detected IDO in the immunosuppressive supernatant of all co-cultures. Removal of IDO decreased the immunosuppression of BMMSCs. Conclusion: SHED, like BMMSCs, produced the IDO enzyme. Although IFN-γ is one of inducer of IDO production in SHED, these cells were not affected by IFN-γ in the same manner as BMMSCs. Unlike BMMSCs, the IDO enzyme did not contribute to their immunosuppression and might have other cell-type specific roles.
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نویسندگان مقاله راضیه علیپور | razieh alipour


معصومه معصومی کریمی | masoumeh masoumi karimi


بتول هاشمی بنی | batool hashemi beni


مینو ادیب | minoo adib


نسرین سرشکی | nasrin sereshki


فرزانه صادقی | farzaneh sadeghi


نشانی اینترنتی http://celljournal.org/journal/article/abstract/4726
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/16/article-16-367055.pdf
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زبان مقاله منتشر شده en
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