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Cell Journal، جلد ۱۸، شماره ۱، صفحات ۴۶-۵۱
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عنوان انگلیسی Micronuclei Assessment of The Radioprotective Effects of Melatonin and Vitamin C in Human Lymphocytes
چکیده انگلیسی مقاله Objective: Critical macromolecules such as DNA maybe damaged by free radicals that are generated from the interaction of ionizing radiation with biological systems. Melatonin and vitamin C have been shown to be direct free radical scavengers. The aim of this study was to investigate the in vivo/in vitro radioprotective effects of melatonin and vitamin C separately and combined against genotoxicity induced by 6 MV x-ray irradiation in human cultured blood lymphocytes. Materials and methods: In this experimental study, fifteen volunteers were divided into three groups of melatonin, vitamin C and melatonin plus vitamin C treatment. Peripheral blood samples were collected from each group before, and 1, 2 and 3 hours after melatonin and vitamin C administration (separately and combined). The blood samples were then irradiated with 200 cGy of 6 MV x-ray. In order to characterize chromosomal aberrations, the lymphocyte samples were cultured with mitogenic stimulus on cytokinesisblocked binucleated cells. Results: The samples collected 1hour after melatonin and vitamin C (separately and combined) ingestion exhibited a significant decrease in the incidence of micronuclei compared with their control group (P< 0.05). The maximum synergic protection and reduction in frequency of micronuclei (57%) was observed 1 hour after vitamin C and melatonin administration combined. Conclusion: We conclude that simultaneous administration of melatonin and vitamin C as radioprotector substances before irradiation may reduce genotoxicity caused by x-ray irradiation.
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نویسندگان مقاله آرام رستمی | aram rostami


سید اکبر موسوی | seyed akbar moosavi


حسن دیانت مقدم | hassan dianat moghadam


افتخار رجب بلوکات | eftekhar rajab bolookat


نشانی اینترنتی http://celljournal.org/journal/article/abstract/3986
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/16/article-16-367103.pdf
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زبان مقاله منتشر شده en
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