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Cell Journal، جلد ۱۷، شماره Suppl ۱، صفحات ۱۷-۱۸
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عنوان انگلیسی Is-25: Establishing and Maintaining Stem Cells
چکیده انگلیسی مقاله Objective: Distinct gene regulatory networks operate in different anatomical locations to give rise to skeletal muscle stem and progenitor cells. One question is the requirement for 3 cell fate determinants, Myf5, Myod and Mrf4, to establish muscle cell fate. Another is how stem cells are maintained throughout tissuegenesis. Materials and Methods: Genetic lineage tracing studies combined with cell ablations and conditional expression of Notch pathway are employed in geneticallymodified mice to examine in vivo relationships of stem and differentiated cells. Results: Was gene duplication of critical cell fate determinants during evolution associated with duplication of the lineage to introduce a failsafe mechanism in case of tissue failure, or do these determinants act within a single lineage? We performed cell ablation studies using combinations of mouse mutants to address this question. We also show the cell fate determinants act in one progenitor cell lineage in contrast to a prevailing model proposed. We show also that prenatal muscle stem cells are maintained by constitutive expression of Notch. Conclusion: Our findings lead us to propose that the myogenic cell fate determinants act largely in a single progenitor population and therefore distinct lineages are not contributing to the heterogeneity of the adult stem cell population. Furthermore, Notch signaling is compatible with muscle stem cell maintenance and proliferation, as well as maintaining the adult quiescent muscle stem cell state.
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نویسندگان مقاله sh تاج بخش | sh tajbakhsh


نشانی اینترنتی http://celljournal.org/journal/article/abstract/49
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