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Cell Journal، جلد ۱۷، شماره Suppl ۱، صفحات ۱۹-۱۹
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عنوان انگلیسی Os-1 :Allogeneic Stem Cell Transplantation for Myelofibrosis in The JAK1/JAK2 Inhibitor Era
چکیده انگلیسی مقاله Objective: Allocating patients with myelofibrosis (MF) to allogeneic hematopoietic cell transplantation (HCT) is complex. Patient-, MF-, and transplantation-related aspects need to be considered for decision making The JAK1 and JAK2 inhibitor ruxolitinib is effective in decreasing symptomatic splenomegaly, and MF-related symptoms. However, HCT remains the only curative option. We evaluated the impact of ruxolitinib treatment prior to HCT on outcome after HCT. Materials and Methods: A cohort of 14 patients with MF (median age 58 years) were treated with the JAK1/JAK2 inhibitor ruxolitinib and received subsequently HCT from related (n=3), and unrelated (n=11) donors after a median exposure to ruxolitinib of 6.5 months. At HCT, MF-risk for survival according to the International Prognostic Scoring System was intermediate-2 or high risk in 86% of patients. Results: Under ruxolitinib, MF-related symptoms were ameliorated in 10 (71.4%) patients and the palpable spleen reduced by a median of 41% in 7 (64%) of 11 patients with splenomegaly. Engraftment occurred in 13 (93%) patients. Acute graft versus host disease (GvHD) grade-III occurred in 2 (14%) patients. Survival, event-free survival, and treatment-related mortality were 78.6, 64, and 7%, respectively. Conclusion: Through the reduction in both cytokines and splenomegaly with ruxolitinib as well as improvement in performance status, ruxolitinib might improve outcome after allogeneic HCT in patients with MF. The down-regulation of inflammatory cytokines might have a beneficial impact on graft failure and acute GVHD. potential risks assosiated with the use of JAK1/JAK2 inhibitors in the transplant setting such as cytokine rebound and the impact of immunmodulation on infections need to be carefully studied.
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نویسندگان مقاله | hk al ali


n jaekel | n jaekel


g behre | g behre


a behning | a behning


c wickenhauser | c wickenhauser


t lange | t lange


d niederwieser | d niederwieser


نشانی اینترنتی http://celljournal.org/journal/article/abstract/54
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