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Cell Journal، جلد ۱۷، شماره Suppl ۱، صفحات ۲۱-۲۱
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عنوان انگلیسی Ps-1: A Modified Model of Primary Cilium to Investigate its Response to Fluid Flow
چکیده انگلیسی مقاله Objective: The primary cilium is an organelle which occurs singly on nearly every cell in the vertebrate body. They are considered important in the osteogenic lineage specification of mesenchymal stem cells (MSC) and human adipose-derived stem cells (hASC). In this study, we simulated the primary cilium using a modified model to derive the experienced strain and stress, which are determining factors in function of stretch-activated ion channels. Located in the membrane of the cilium base, these channels play a pivotal role in many cilia-related reactions and diseases. Materials and Methods: Primary cilia, organelles which comprise a growing area of investigation in bone tissue engineering, are being studied using a new model in this piece of research. We thought of primary cilium as a beam which is attached to the cell through an ideal torsion spring. This model is then submerged in the fluid, which exerts the driving shear force, and is subsequently analyzed using finite element methods and fluid-structure interaction techniques. Results: The analysis is carried out using COMSOL multiphysics. The model is a two dimensional strip which is bound to the cell by means of a thin layer with adjustable spring constant, while it is free to bend in response to the fluid flow. As a result, cilium experiences considerable stress at the base, which is why scientists think of it as a cellular mechanosensor. We have seen that applying such a boundary condition decreases stress by 40% in our approximate model. Conclusion: In previous studies the primary cilium was mathematically modeled using a cantilevered beam which was at a fixed angle with respect to the cell. This assumption, however, leads to an oversimplified model which in turn, gives rise to misleading results. We have shown that inclusion of a torsion spring dramatically reduces the maximum stress experienced by the cilium.
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نویسندگان مقاله راد a عباس زاده | rad a abbasszadeh


b وحیدی | b vahidi


نشانی اینترنتی http://celljournal.org/journal/article/abstract/57
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