این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Cell Journal، جلد ۱۷، شماره Suppl ۱، صفحات ۳۲-۳۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Ps-28: The Effects of Different Times Mesenchymal Stem Cells Injection on Brain Stroke in Rats
چکیده انگلیسی مقاله Objective: Brain stroke is one of serious problems which leads to disability and morbidity. There is no effective treatment recovering neurological functions. Recently, cell therapy with mesenchymal stem cells transplantation opens a hopeful window to approach to brain stroke because of their neuro-protection and antiapoptotic effects. In this study, we design an experiment to define the optimum time for injecting mesenchymal stem cells (MSCs) and get the best neurological outcome. Materials and Methods: The MSCs were isolated from Sprague Dawley rats’ tibias and femurs and they were expanded till passage 4. Some Mesenchymal stem cell markers were assessed for isolated cells including CD44, CD90, CD29 and CD34. The middle cerebral artery occlusion (MCAO) was performed to induce brain stroke. The MSCs were injected in different time containing 1 hour, 12 hours, 1 day, 3 days, 5 days and 7 days after MCAO. The neurological function and brain damage were evaluated for 28 days after MSCs transplantation. Results: The isolated MSCs were positive for CD44, CD90, and CD29 and negative for CD34. The examination for neurological function shows that injection of MSCs in 12 hours after MCAO had the best effect through other groups and it has also the least brain volume damage. Conclusion: The injection of MSCs in 12 hours after MCAO is an effective way to reduce the brain stroke consequences, in addition it makes brain damage less than the other time MSCs injection.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله sm حسینی | sm hosseini


m فرهمندنیا | m farahmandnia


z رضی | z razi


s دلاوری | s delavari


نشانی اینترنتی http://celljournal.org/journal/article/abstract/84
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات