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Cell Journal، جلد ۱۷، شماره Suppl ۱، صفحات ۳۳-۳۴
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عنوان انگلیسی Ps-30: Combination Cell Therapy with Mesenchymal Stem Cells and Neural Stem Cells for Brain Stroke in Rats
چکیده انگلیسی مقاله Objective: Brain stroke is the second most important events that lead to disability and morbidity these days. Although, stroke is important, there is no treatment for curing this problem. Nowadays, cell therapy has opened a new window for treating central nervous system disease. In this study, we have designed an experiment that the combination cell therapy mesenchymal and neural stem cells was used for brain stroke. Materials and Methods: The mesenchymal stem cells (MSCs) were isolated from adult rat bone marrow and the neural stem cells were isolated from ganglion eminence of rat embryo 14 days. The MSCs were injected 1 day after middle cerebral artery occlusion (MCAO) and the neural stem cells transplanted 7 days after MCAO. After 28 days, the neurological outcomes and brain lesion volumes were evaluated. Also, the activity of Caspase 3 was assessed in different groups. Results: The group which received combination cell therapy had better neurological examination and less brain lesion. Also the combination cell therapy group had the least Caspase 3 activity among the groups. Conclusion: MSCs therapy is more effective than Mesenchymal stem cell therapy and neural stem cell therapy separately for treating the brain stroke in rats.
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نویسندگان مقاله sm حسینی | sm hosseini


m فرهمندنیا | m farahmandnia


z رضی | z razi


s دلاوری | s delavari


b shakibajahromi | b shakibajahromi


f ثابت سروستانی | f sabet sarvestani


نشانی اینترنتی http://celljournal.org/journal/article/abstract/86
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