این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Cell Journal، جلد ۱۷، شماره Suppl ۱، صفحات ۳۴-۳۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Ps-31: Behavior of Human Induced Pluripotent Stem Cells on Electrospun PCL Nanofibers and PCL Film
چکیده انگلیسی مقاله Objective: Extracellular matrix (ECM) components play a critical role in regulating cell behaviors. Interactions between ECM components and cells are important in various biological processes, including cell attachment, survival, morphogenesis, spreading, proliferation, and gene expression. In this study the in vitro responses of human induced pluripotent stem cells (hiPSCs) on polycaprolactone (PCL) electrospun nanofibrous scaffold were reported in comparison with those of the cells on corresponding solution-cast film scaffold. Materials and Methods: The properties of the scaffolds were investigated by fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) and The resulting cells were analyzed for adhesion genes and protein expression by qRT-PCR and immunocytochemistry. Results: Our results demonstrated that the nanofibrous scaffold showed better support for the attachment and proliferation of hiPSCs than their corresponding film scaffold. Indeed, toxicity test indicated that the electrospun nanofibrous scaffold was more biocompatible than PCL solution-cast film scaffold and nanofibrous scaffold could significantly improve the cell viability of hiPSCs. Conclusion: Consequently, we emphasize that hiPSCs can sense the physical properties and chemical composition of the materials and regulate their behaviors accordingly and Nanofiberous PCL scaffold can be used as a suitable broad spectrum scaffold for hiPSCs.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله e حویزی | e hoveizi


s ابراهیمی باروق | s ebrahimi barough


sh توکل | sh tavakol


a چاوشیان | a chavoshian


نشانی اینترنتی http://celljournal.org/journal/article/abstract/87
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات