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Cell Journal، جلد ۱۷، شماره Suppl ۱، صفحات ۳۶-۳۷
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عنوان انگلیسی Ps-37: Transplantation of Human Induced Neural Progenitor Cells to The Contusion Model of Rat Spinal Cord Injury
چکیده انگلیسی مقاله Objective: Traumatic injury to the spinal cord causes cell death, demyelination, axonal degeneration, and cavitation resulting in functional motor and sensory loss. Stem cell therapy is a promising approach for spinal cord injury (SCI). Various cell types have been transplanted into the injured rat spinal cord and most of them resulted in functional recovery. Although neural progenitor cells (NPCs) had the best results because of the similarity of spinal cord to their favorable niche, the major problem is that they are not autologous. Materials and Methods: In this study, we transplanted human induced neural progenitor cells (hiNPCs) which were trans-differentiated from adult human fibroblasts by the force defined transcription factors into the injured spinal cord of adult Wistar rats at 6 days after injury. Behavioral analyses were performed from the time of the initial injury until 7 weeks after SCI. Results: Our results show the presence of a substantial number of surviving hiNPCs in the injured spinal cord up to 6 weeks after transplantation. Grafted hiNPCs survived and differentiated into the three major neural lineages (neurons, astrocytes, and oligodendrocytes). These cells also migrate to the rostral and caudal parts of the rat spinal cord. Furthermore, we observed that injured rats receiving hiNPC transplants had improved functional recovery as assessed by the Basso, Beattie, and Bresnahan Locomotor Rating Scale and grid-walk analysis. Conclusion: Our data provide strong evidence in support of the feasibility of iNPCs for cell-based therapy in patient with SCI.
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نویسندگان مقاله m کشکولی | m kashkouli


e شهبازی | e shahbazi


mh اصغری | mh asghari


h بهاروند | h baharvand


s کیانی | s kiani


نشانی اینترنتی http://celljournal.org/journal/article/abstract/93
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