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Cell Journal، جلد ۱۷، شماره Suppl ۱، صفحات ۳۹-۴۰
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عنوان انگلیسی Ps-43: Bioinformatic Evaluation of miR-548aa and rs13423759 in 3'UTR of ErbB4 as A Potential Prognostic Biomarker in Breast Cancer
چکیده انگلیسی مقاله Objective: Breast cancer is the most common cause of cancer death among women worldwide. Aberration in signal transduction pathway of ErbB family in human tumors is a common phenomenon. ErbB4 as an oncogene and also tumor suppressor is one of the members of ErbB family. ErbB4 overexpression has been observed in approximately 50% of breast cancer cases.miRNAs are the large subgroup of noncoding RNAs with 18-25 nucleotides inhibiting the expression of target genes by means of binding to their 3'UTR. They can also play role as an oncogene and/or tumor suppressor. In recent years, the association of some SNPs located in either miRNA seeds or 3'UTR of their target genes with the risk of breast cancer have been proved in some populations. Materials and Methods: miRNASNP database was used to identify the miRNAs with the ability to bind to the 3'UTR of ErbB4 transcripts. In next step, miRTar- Base and DAVID databases were used to investigate the function and the related signaling pathways of obtained miRNAs. Results: In silico investigation of SNPs in the 3'UTR of ERBB4 gene showed that rs13423759 could alter the binding properties of miR-548aa. By reviewing the literature and with regards to molecular enrichment analysis from miRWalk and DAIVID database, we realized that miR548aa targetome could act in some molecular signaling pathways such as: PI3K-AKT, JAK/STAT and MAPK signaling pathways; therefore, miR-548aa could be considered as an oncomiRNA. Since SNP rs13423759 causes loss of binding between miR-548aa and its target (ERBB4), this SNP could be proposed as a good-prognostic factor by reducing the activity of miR-548aa. Conclusion: SNP rs13423759 could function as a good prognostic factor by disrupting the repressive activity of miR548aa
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نویسندگان مقاله m منصوری bidakani | m mansoury bidakani


نشانی اینترنتی http://celljournal.org/journal/article/abstract/99
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