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Cell Journal، جلد ۱۷، شماره ۳، صفحات ۴۷۱-۴۹۷
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عنوان انگلیسی Upregulation of RHOXF2 and ODF4 Expression in Breast Cancer Tissues
چکیده انگلیسی مقاله Objective: During the past decade, the importance of biomarker discovery has been highlighted in many aspects of cancer research. Biomarkers may have a role in early detection of cancer, prognosis and survival evaluation as well as drug response. Cancer-testis antigens (CTAs) have gained attention as cancer biomarkers because of their expression in a wide variety of tumors and restricted expression in testis. The aim of this study was to find putative biomarkers for breast cancer. Materials and Methods: In this applied-descriptive study, the expression of 4 CTAs, namely acrosin binding protein (ACRBP), outer dense fiber 4 (ODF4), Rhox homeobox family member 2 (RHOXF2) and spermatogenesis associated 19 (SPATA19) were analyzed at the transcript level in two breast cancer lines (MCF-7 and MDA-MB-231), 40 invasive ductal carcinoma samples and their adjacent normal tissues as well as 10 fibroadenoma samples by means of quantitative real-time reverse transcription polymerase chain reaction (RT-PCR). Results: All four genes were expressed in both cell lines. Expression of ODF4 and RHOXF2 was detected in 62.5% and 60% of breast cancer tissues but in 22.5 and 17.5% of normal tissues examined respectively. The expression of both RHOXF2 and ODF4 was upregulated in cancerous tissues compared with their normal adjacent tissues by 3.31- and 2.96-fold respectively. The expression of both genes was correlated with HER2/neu overexpression. RHOXF2 expression but not ODF4 was correlated with higher stages of tumors. However, no significant association was seen between expression patterns and estrogen and progesterone receptors status. Conclusion: ODF4 and RHOXF2 are proposed as putative breast cancer biomarkers at the transcript level. However, their expression at protein level should be evaluated in future studies.
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نویسندگان مقاله گلنسا کاظمی اولی | golnesa kazemi oula


سوده غفوری فرد | soudeh ghafouri fard


مریم بیگم مباشری | maryam beigom mobasheri


لعبت گرانپایه | lobat geranpayeh


محمد حسین مدرسی | mohammad hossein modarressi


نشانی اینترنتی http://celljournal.org/journal/article/abstract/8
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/16/article-16-367215.pdf
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زبان مقاله منتشر شده en
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