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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۷-۷
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عنوان انگلیسی Is-6: Bioengineer Attempts to (Re-) Generate New Nephrons and The Kidney
چکیده انگلیسی مقاله Chronic kidney disease (CKD) is a global public health problem whose prevalence has been estimated to be 8-16% of the population worldwide. Eventually endstage renal disease (ESRD) occurs every year in 0.15- 0.2% of patients with overt CKD, and renal replacement therapy (RRT) with dialysis or transplantation is required. Although approximately 2 million people are currently on RRT to sustain life worldwide, this likely represents less than 10% of those who need it. The kidney transplant approach is also seriously impaired by eventually limited graft survival and by the scarce availability of donors. Innovative tissue engineering strategies have been recently proposed to overcome these unmet needs. Recent advances in our understanding of the developmental biology of the kidney, along with the establishment of novel methodologies in the field of regenerative medicine, have created significant potential for kidney regeneration. These advances include construction of novel kidney tissue from suspensions of single cells of metanephric origin. Another innovative tool under current investigation rests on the idea of using decellularized kidneys for engineering a new functional organ as potential future treatment option for ESRD. In the last five years several interesting observations have been reported on the possibility to used an acellular matrix from the whole kidney and the attempt to recellularize this scaffold using stem or differentiated cells. Despite difficulties in achieving the important goal of kidney engineering into the laboratory, the currently tested methodologies are offering new chances to possibly regenerate the kidney from patients with CKD in the near future.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/300
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