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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۷-۷
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عنوان انگلیسی Is-7: Mesenchymal Stem Cells as A Cure for Acute Kidney Injury
چکیده انگلیسی مقاله Acute kidney injury (AKI) is emerging as a public health problem in developing and developed country that affects up to 7% of hospitalized patients with higher prevalence in critical care unit. Despite major advances in preventive strategies and support measures, the mortality rate among patients remains higher than 50%. Several pharmacological approaches to improve renal function and survival after AKI episode have been largely unsuccessful in clinical practice. New hopes of innovative interventions to enhance the limited capability of kidney regeneration in AKI comes from stem cell-based therapy with mesenchymal stromal/stem cells (MSC) that represent an attractive tool by virtue of their unique properties, of homing damaged tissues and the regenerative capacity. Tubular epithelial cells that after acute ischemic or toxic insults undergo dysfunction and detachment and are key target for cell therapy in AKI. MSC have been proved effective in curing experimental AKI. The mechanisms underlying the reno-protective effect in preclinical models of AKI has been evaluated, together with modalities by which MSC interact with damaged cells via release of soluble factors and exosomes/microvescicles. Several biological effects of the identified mediator will be analyzed in the lecture including anti-apoptotic, promitogenic, immunomodulatory and anti-inflammatory activities. The mechanisms of stem cell homing and engraftment to sites of tissue damage will be discussed. Conclusion: Translation of preclinical data with stem cells into effective and safe new modalities of care is still limited and further studies are needed before moving to patients with AKI.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/301
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