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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۳-۱۳
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عنوان انگلیسی Is-13: Kidney Regeneration – Tubular Perspective
چکیده انگلیسی مقاله Objective: Acute kidney injury with tubular necrosis is a major complication of critical illness with high morbidity and mortality. To date it has not been clear whether tubular regeneration occurs out of a progenitor pool or whether resident tubular cells start proliferating. Materials and Methods: Genetic fate mapping using several distinct promotors targeting different tubular cells combined with ischemia/ reperfusion (I/R) injury to precisely identify and quantify regeneration. Results: Genetic labelling experiments were performed both with differentiated tubular cells and scattered tubular cells, which have been regarded as a tubular cell progenitor niche. Inducing I/R in both genetically labeled mouse lines revealed that proliferation after I/R injury only occurs out of the differentiated tubular cells. Several cellular markers were identified which characterize this dedifferentiation and proliferation process. Conclusion: In summary, these cell fate tracking experiments of regeneration establish that regeneration of tubular cells after I/R occurs from any surviving tubular cell. Tubular cells appear to switch to a common injury response program characterized by the expression of a specific set of scattered tubular cell markers.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/307
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