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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۲۴-۲۴
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عنوان انگلیسی Is-25: Bioinspired Scaffold, Hydrogel and Stem Cell Based Strategies for Engineering Distinct Tissues
چکیده انگلیسی مقاله Objective: The proper selection of a scaffold/matrix material is both a critical and a difficult choice that will determine the success or failure of any tissue engineering or regenerative medicine (TERM) strategy. In many cases a wide range of properties have to be carefully tuned for a specific application and to the use of specific cell populations. We believe that natural origin polymeric biomaterials and bioinspired materials and processing routes and are the best choice for many distinct approaches. We have been working with this type of systems for the past 20 years, proposing a wide range of possibilities for the engineering of many different tissues. In addition, we have been publishing on an all range of innovative processing methodologies to produce adequate scaffolds/ hydrogels for different TERM applications. Furthermore an adequate cell source should be selected. In many cases efficient cell isolation, expansion and differentiation methodologies should be developed and optimized. In our research group we have developed many different strategies to deal with these issues. Materials and Methods: We have been using different human cell sources namely: mesenchymal stem cells from bone marrow, mesenchymal stem cells from human adipose tissue, human cells from amniotic fluids and membranes and cells obtained from human umbilical cords. The potential of each type of cells, to be used to develop novel useful regeneration therapies has been studied. In many cases this involves the development of adequate co-culture methodologies. Cell uses and their interactions with different natural origin degradable scaffolds, hydrogels, and distinct nano and micro-carriers, and smart release/differentiation systems was assessed. The studied materials include: starch based polymers, chitin, chitosan, gellan gum, casein, soy, algae based materials (ulvan, carragenan, algae derived ceramics), silk fibroin, gelatin, hyaluronic acid, marine collagen, among many others. These different materials have been used to try to engineer different types of tissues, namely: bone, cartilage, osteochondral defects, intra-vertebral disk, skin, neurological tissues, tendon and meniscus Results: In our research a great focus is given to the different sources of stem cells, the isolation of distinct sub-populations, ways of differentiating them, as well as their interactions with different 3D architectures and natural origin materials for culturing them. The use of bioreactors to control cell differentiation, as well as the surface modification of the materials in order to control cell adhesion and proliferation has also been studied in great detail. Several examples of biomimetic and nanotechnology based strategies to engineer an all range of distinct tissues will be described in the presentation. Conclusion: Several 3D-architectures, novel hydrogel systems, biomimetic and nanotechnology based strategies to engineer different types of tissues will be described based on our many contributions to the literature in these fields. Examples for different combinations of natural materials and stem cells, and their application on the engineering of different tissues will be addressed.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/319
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