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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۳۳-۳۳
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عنوان انگلیسی Ps-1: Evaluation of Expression of ZFX Gene in Human Astrocytoma Brain Tumors
چکیده انگلیسی مقاله Objective: Astrocytomas are a type of cancer of the brain which are originated from astrocytes. Astrocytomas are the most common glioma. In recent years, stemlike tumor cells in glioma are detected. The zinc finger transcription factor, ZFX is an important regulator of self-renewal in multiple stem cell types. Moreover, ZFX expression abnormally increases in various cancers such as prostate adenocarcinoma, diffuse large B-cell lymphoma and follicular lymphoma. Materials and Methods: In the current study, we used quantitative real time RT-PCR method for evaluation of ZFX expression in 25 human astrocytoma tumoral tissues with different grades. Fold changes in the expression of the target transcript were determined using the ΔΔCt method. Pvalues less than 0.05 were considered as statistically significant. Furthermore, the association of gene expression with various clinicopathological characteristics such as tumor grade, tumor size, gender, invasion, mitosis index, glomeroluid vessel formation, calcification and age were examined. Results: We found that there is a significant association between ZFX gene expression and different tumor grades (p value = 0.008), the presence or absence of invasion (p value = 0.001), forming and non-forming of gelomeruloid vessels (p value = 0.002), the age over or under 50 years (p value = 0.001) and the presence or absence of calcification (p value = 0.001). Conclusion: In overal, our results showed that there is a significant association between ZFX gene expression and various clinicopathological characteristics in astrocytomas. Our results implicate that ZFX contributes to the invasion of neoplastic cells, at least in part by neovasculogenesis. Due to this, ZFX may have the potential to be used as a target for therapeutic interventions in brain cancers.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/327
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