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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۳۴-۳۴
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عنوان انگلیسی Ps-2: Evaluation of ZFX Expression in Meningioma
چکیده انگلیسی مقاله Objective: The zinc finger transcription factor ZFX gene is situated on the mammalian X-chromosome. ZFX functions as an important regulator of self-renewal in various stem cell types such as embryonic and hematopoietic stem cells. That is very conserved between vertebrates. Furthermore, ZFX expression is abnormally elevated in several cancers, and positively correlates with tumor grade. Meningiomas are a diverse set of tumors arising from the meninges, the membrane layers surrounding the central nervous system. Meningiomas account for about 20% of all primary intracranial tumors. Recently, the presence of mesenchymal stem-like cells was proved in the meningiomas. Materials and Methods: Due to this, for the first time, we examined the expression of ZFX using quantitative real time RT-PCR method in 25 meningioma tumoral tissues with different grades. Fold changes in the expression of the target transcript were determined using the Livakˊs method. P-values less than 0.05 were considered as statistically significant. Furthermore, the association of gene expression with clinicopathological characteristics such as tumor grade and gender were examined. Results: We found that there is a significant inverse association between ZFX gene expression and different tumor grades (p value = 0.028) and gender (p value = 0.009). Conclusion: Therefore, it seems that ZFX may play a role in the initiation of meningioma and can be used as a therapeutic target in the future.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/328
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