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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۵۳-۵۳
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عنوان انگلیسی Ps-21: Biodegradation and Biocompatibility Evaluation of Mgsubstituted Fluorapatite Coating Using SBF and Proliferation of Dental Pulp Mesenchymal Cells
چکیده انگلیسی مقاله Objective: Many efforts have been made to improve the connection of implant material with hard tissue. Ability to establish a direct link between hydroxyapatite and bone hard tissue is due to the similarity of their chemical and biological structure. In our previous study construction and characterization of Mg-substituted fluorapatite coating was examined. Materials and Methods: In the present study, invitro behaviour of Mg-substituted fluorapatite was evaluated. The biodegradation and bioactivity of prepared samples were evaluated by immersing the samples in the simulated body fluid (SBF) for various periods under physiological conditions. We also examined the growth rate and proliferation of dental pulp derived mesenchymal stem cells using on Mg-substituted fluorapatite coating via MTS test. Results: According to our data, the pH value of SBF containing the coated samples increased at the first day of experiment followed by a decreasing trend thereafter. The increase of the pH value observed at the first day was due to the dissolution of the coatings and the subsequent decline of pH was caused by sedimentation of apatite on the surface of the samples. By increasing of magnesium in the coatings, we found a reduction in PH of the solutions. This was due to further sedimentation of magnesium in the solutions, which indicated the merit of Mg-substituted fluorapatite than fluorapatite coating. Also, according to the MTS test results, a partial more proliferation rate was observed in Dental pulp cells cultured on the Mg-substituted fluorapatite coverage compared to conventional cell culture plates. Conclusion: Overall, the results of this research indicated the suitability of Mg-substituted fluorapatite coating more than fluorapatite coating due to the greater deposition of apatite on the surface, as well as the appropriate growth and proliferation of dental pulp derived mesenchymal cells on the Mg-substituted fluorapatite coating.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/347
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