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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۶۰-۶۰
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عنوان انگلیسی Ps-28: Effects of Steroid Hormones on The Expression Pattern of Plueripotency Markers in The Mice Uterine Tissue
چکیده انگلیسی مقاله Objective: It has been suggested that endometrial stem cells are likely responsible for endometrial regeneration. The aim of this study was to investigate the effect of estradiol and progesterone hormones on the Oct4 and Sox2 mRNA expression of uterine tissue in the ovariectomized mice. Materials and Methods: Adult female NMRI mice were underwent ovariectomy. Two weeks later, the mice were treated with 17β-estradiol, progesterone and combination of estradiol and progesterone for 5 days and then were sacrificed and their uterus removed. Quantitative Real time PCR of pluripotency markers (Oct4 and Sox2) was performed. Results: Comparison of the normalized cycle of threshold (CT) values revealed that levels of Oct4 gene expression in the estradiol - progesterone combined treatment group in comparision to other groups was significantly decreased (p< 0.05). Whereas There were no significant differences between Oct4 gene expression in the control, estradiol, Progesterone groups (p>0.05). Levels of Sox2 gene expression in the 17β-estradiol treated and estradiol - progesterone combined treatment groups were significantly decreased in comparision to other groups (p< 0.05). Conclusion: The present study indicated that expression of the Oct4 and Sox2 mRNA in the uterine tissue were affected by steroid hormones.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/354
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