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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۶۱-۶۱
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عنوان انگلیسی Ps-29: A Heparin Binding Growth Factor Concentration in Association with Inflammatory Cytokines in Multiple Sclerosis Patients
چکیده انگلیسی مقاله Objective: A heparin-binding growth factor known as Midkine (MK) possess various effects in different tissues of the body, including an important role in induction of oncogenesis, inflammation and restoration of tissues. MK with promoting effects in inflammatory responses through enhancing the leukocytes migration in multiple sclerosis (MS) patients. The present study aimed to assess the concentration of this growth factor which correlated to inflammatory cytokines.Materials and Methods: To evaluate the MK levels and its relationship with inflammatory cytokines (IL-17 and IL-23) in MS patients, the serum concentration of these proteins was assessed by ELISA in 32 MS patients in comparison with 32 healthy subjects. Results: Our results showed that the MK concentration in MS patients is lower than healthy controls. Also we observed a significant decrease in IL-23 cytokine levels in MS patients. Conclusion: There was a significant correlation between MK and IL23 concentrations in our study cohort. These results confirms a role for MK in inflammatory reactions in MS.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/355
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