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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۶۲-۶۲
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عنوان انگلیسی Ps-30: Assessment of Circulating Endothelial Progenitor Cells in Multiple Sclerosis Patients with Optic Neuritis Attack
چکیده انگلیسی مقاله Objective: Optic neuritis (ON) is inflammation of the optic nerve. In multiple sclerosis (MS) acute demyelization of optic nerve is a common cause of ON in some parts. Endothelial progenitor cells (EPCs) are present in circulation and contribute to vasculogenesis in adults. The aim of present study was to determine the number of circulating EPCs in MS patients with ON. Materials and Methods: Blood samples were collected from 50 MS patients with ON and 40 healthy individuals (mean ages: 26 ± 5). Together with the collection of demographic data, a sample of venous blood was drawn to assess a complete blood count with differential; circulating, VEGF2, CD31, CD144 and CD309 as ECs markers and CD34 as hematopoietic cell marker using flow cytometry. Data are expressed as mean ± SD. Results were analyzed statistically, using the Independent sample t test. Values of p< 0.001 were taken as significant. Results: The median absolute percentage of circulating CD34+ HPCs in the overall population of ON patients was 18 ± 9.96. Against in the healthy was 26.31 ± 14.33 % (p< 0.001). Patients with ON had EPCs which it was significantly higher than in healthy controls. In addition, the large number of EPCs but less number of circulating CD34 hematopoietic progenitor cells detected in patients. Conclusion: Overall, data indicated EPCs circulate in peripheral blood of MS patients with an early phase of ON. It seems to increase of EPC relates to a good outcome. It may be that Heightened mobilization of EPCs represents an important role in prevention from BBB disruption or may be caused neoangiogenesis in MS patients with ON.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/356
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