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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۶۴-۶۴
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عنوان انگلیسی Ps-32: The Effects of Poly I-C Treated Mouse Bone Marrow-Derived Mesenchymal Stromal Cells and Its Supernatant on NK Cells Activity against Yac-1 Cell Line
چکیده انگلیسی مقاله Objective: Mesenchymal stromal cells (MSCs) are multipotent, non-hematopoietic precursor cells that could be found in many adult textures. Multipotency and immunomedulatory potential of MSCs makes these cells as a remarkable tools for treatment of some diseases. It seems that stimulation of toll like receptors expressed on the surface of mesenchymal stromal cells may be potentiated immunomedulatory effects of these cells. This study was done to investigate the effects of polarized bone marrow-derived mesenchymal stromal cells of mouse and its supernatant on cytotoxic activity of natural killer (NK) cells. Materials and Methods: MSCs isolated from bone marrow of femur and tibia of NMRI-mice. Third passage of cells were treated with Poly:IC. Then the effects of polarized MSCs and its supernatant evaluated on cytotoxic activity of NK Cells on lymphoid cancer cells Yac-1 (as target cells) using flow cytometery. Results: MSCs treated with poly I-C and its supernatant made the survival rate of Yac-1cells increased and the percent of dead cells (apoptosis and necrosis) decreased in comparison to untreated MSCs. Conclusion: MSCs treated with poly I-C and its supernatant inhibited the cytotoxic effects of NK cells on Yac-1 cell line.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/358
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