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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۶۵-۶۵
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عنوان انگلیسی Ps-33: Evaluation of LPS Treated Mouse Bone Marrow-Derived Mesenchymal Stromal Cells and Its Supernatant on NK Cells Activity Against Yac-1 Cell Line
چکیده انگلیسی مقاله Objective: Mesenchymal stromal cells (MSCs) are multipotent, non-hematopoietic precursor cells that could be found in many adult textures. Multipotency and immunomedulatory potential of MSCs makes these cells as a remarkable tools for treatment of some diseases. It seems that stimulation of toll like receptors expressed on the surface of mesenchymal stromal cells may be potentiated immunomedulatory potential of these cells. This study was done to investigate the effects of polarized bone marrow-derived mesenchymal stromal cells of mouse and its supernatant on the cytotoxic activity of natural killer (NK) cells. Materials and Methods: MSCs were isolated from bone marrow of femur and tibia of NMRI-mice. Third passage of cells were treated with LPS. Then the effects of polarized MSCs and its supernatant evaluated on cytotoxic activity of NK Cells on lymphoid cancer cells Yac-1 (as target cells) using flow cytometery . Results: MSCs treated with LPS and its supernatant made the survival rate of Yac-1cells decreased and the percent of dead cells (apoptosis and necrosis) increased in comparison to untreated MSCs. Conclusion: This results indicated that MSCs treated with LPS and its supernatant decreased the inhibitory effects of MSCs on NK cells.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/359
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